7/25/2023 0 Comments T mobile plans for 4 lines 201913Ĭlinical trials in AGA patients treated with 2% or 5% MS showed a remarkable increase in hair growth and decrease in hair loss, and superior results were evident with the 5% formulation. There was an increase in the rate of DNA synthesis in anagen bulbs, suggesting that minoxidil stimulated secondary hair germ cells of telogen follicles and caused a rapid shift to the anagen phase. 2 Mori and Uno discovered that MS shortened the telogen phase to 1 to 2 days in treated rats compared to approximately 20 days in untreated rats. ![]() ![]() Termination of treatment results in progressive hair loss within 12 and 24 weeks. The medication affects follicular cells by enhancing hair growth and reducing hair loss. Minoxidil has been used for hair loss treatment for several decades. Approximately 95% of the systemically absorbed drug and its metabolites are excreted via the kidney within 4 days. Minoxidil does not bind to plasma proteins or crosses the blood–brain barrier. Systemic absorption of topical minoxidil is less than 99% of the amount applied on the scalp. Pharmacokinetically, approximately 1.4% of topical minoxidil is absorbed through a normal scalp, while increased absorption is associated with drug concentration, frequency of drug application, and damage to the barrier function of the stratum corneum. Thus, prior or concomitant use of aspirin decreases the clinical response to topical minoxidil. A recent study showed that the follicular enzymatic activity decreased following 14 days of low-dose aspirin use. 10 Salicylate and aspirin can inhibit sulfotransferase. It is noteworthy that there is no correlation between the serum or tissue concentration of minoxidil and hair growth. 9 There are two phenol sulfotransferases responsible for minoxidil sulfation in the human scalp, and patients with higher enzyme activity responded better to topical minoxidil than those with lower enzyme activity did. The positive effect of minoxidil on hair growth is mainly due to its metabolite, minoxidil sulfate, and the enzyme responsible for this conversion is sulfotransferase, which is located in hair follicles and varies in production among individuals. 7 This theory was further supported by the results of an animal study in which minoxidil increased cellular DNA synthesis and enhanced cell proliferation. 6 Xu et al suggested that K +-channel activity is necessary for progression to the G 1 stage of the cell cycle therefore, it might play a key role in cell proliferation at the early stage. Minoxidil is a potent arteriolar vasodilator that opens potassium channels located on the smooth muscles of the peripheral artery, causing hyperpolarization of the cell membrane. ![]() MF is also more convenient to use, because it dries quicker and spreads less to the peripheral region. Compared to MS, MF allows for increased delivery of the active ingredient to the target site and easy penetration of the drug with less irritation hence, the US Food and Drug Administration (FDA) has granted approval for 5% MF for the treatment of AGA.
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